Cardiovascular risk factors in cognitively impaired nursing home patients: a relationship with pain?

TitleCardiovascular risk factors in cognitively impaired nursing home patients: a relationship with pain?
Publication TypeJournal Article
Year of Publication2007
AuthorsAchterberg WP, Scherder E., Pot A.M, Ribbe M.W
JournalEuropean Journal of Pain: Ejp
Date PublishedAug
ISBN Number1090-3801
Accession Number17157543
Keywords*Cardiovascular Diseases/ep [Epidemiology], *Cognition Disorders/ep [Epidemiology], *Dementia/ep [Epidemiology], *Nursing Homes/sn [Statistics & Numerical Data], *Pain/ep [Epidemiology], Age Distribution, Aged, Aged, 80 and over, Alzheimer Disease/ep [Epidemiology], Alzheimer Disease/pa [Pathology], Alzheimer Disease/pp [Physiopathology], Brain/pa [Pathology], Brain/pp [Physiopathology], Cognition Disorders/pa [Pathology], Cognition Disorders/pp [Physiopathology], Comorbidity, Dementia, Vascular/ep [Epidemiology], Dementia, Vascular/pa [Pathology], Dementia, Vascular/pp [Physiopathology], Dementia/pa [Pathology], Dementia/pp [Physiopathology], Diabetes Mellitus/ep [Epidemiology], Female, Humans, Hypertension/ep [Epidemiology], Male, Middle Aged, Nerve Fibers, Myelinated/pa [Pathology], Netherlands, Neural Pathways/pa [Pathology], Neural Pathways/pp [Physiopathology], Nursing Homes/td [Trends], Pain/pa [Pathology], Pain/pp [Physiopathology], Prevalence, Risk Factors, Sex Distribution

Cardiovascular risk factors (CRF) such as hypertension and diabetes mellitus favour the development of both vascular dementia (VaD) and Alzheimer's disease (AD). The resulting deafferentation may increase the experience of pain in VaD and in AD. The goal of the present study was to examine the relationship between CRF and pain in a sample of 107 cognitively impaired nursing home patients who had also a chronic pain condition. The prevalence of pain in patients with hypertension or diabetes mellitus was higher (25/41=61% of them had pain) than those without diabetes or hypertension (of whom 24/66=36.4% had pain, p=0.017). In a multivariate logistic regression model (adjusted for gender, age and depression) the presence of diabetes or hypertension was a risk indicator for pain: odds ratio: 3.48, p=0.005, 95% CI: 1.45-8.38. This finding supports the hypothesis that as a result of CRF, disruptions of cortico-cortico and cortico-subcortical pathways occur, and consequently, enhances pain in this group of patients.

Short TitleEur J PainEur J Pain
Alternate JournalEur J Pain