| Title | Impact of anticholinergic burden on cognitive performance: a cohort study of community-dwelling older adults |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Nishtala PS, Allore H, Han L, Jamieson HA, Hilmer SN, Chyou T-yuan |
| Journal | Journal of the American Medical Directors Association |
| Volume | 21 |
| Issue | 9 |
| Pagination | 1357 |
| Date Published | Sep |
| ISBN Number | 1538-9375 (Electronic)<br/>1525-8610 (Print)<br/>1525-8610 (Linking) |
| Accession Number | 32402780 |
| Keywords | *Cholinergic Antagonists/adverse effects, *Cognitive Dysfunction/chemically induced/epidemiology, Aged, Cognition, Cohort Studies, Humans, Independent Living |
| Abstract | Older people are susceptible to the adverse effects of anticholinergic medications, including cognitive impairment.1 A systematic review of observational studies reported mixed associations between high anticholinergic burden, a cumulative measure of anticholinergic medications, and cognitive performance in older people.2 Observational studies may have biased estimates of the impact of exposures, as the exposed and unexposed may systematically differ in covariates associated with the outcomes.3 The inverse probability of treatment weight (IPTW) is a causal method used to adjust exposure effect and mitigate confounding by eliminating the strong influence of imbalanced covariates on the exposure.4 In this context, we examined the association between anticholinergic burden and cognitive function in a nationwide community-dwelling older adult sample using the IPTW method for confounding control. |
| DOI | 10.1016/j.jamda.2020.03.027 |
| PMCID | PMC7971451 |
