| Title | Intrinsic capacity and recent falls in adults 80 years and older living in the community: results from the ilSIRENTE Study |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Cacciatore S., Marzetti E., Calvani R., Picca A., Salini S., Russo A., Tosato M., Landi F. |
| Journal | Aging Clin Exp Res |
| Volume | 36 |
| Issue | 1 |
| Pagination | 169 |
| Date Published | Aug 10 |
| ISBN Number | 1720-8319 (Electronic)<br/>1594-0667 (Print)<br/>1594-0667 (Linking) |
| Accession Number | 39126523 |
| Keywords | *Accidental Falls/statistics & numerical data, *Activities of Daily Living, *Independent Living, Adl, Aged, 80 and over, Aging/physiology, cognitive decline, dementia, disability, falls, Female, Frailty, Functional reserve, Geriatric Assessment/methods, hip fracture, Humans, Intrinsic capacity, Male, malnutrition, Risk Factors |
| Abstract | BACKGROUND: Falls in older adults significantly impact overall health and healthcare costs. Intrinsic capacity (IC) reflects functional reserve and is an indicator of healthy aging. AIMS: To explore the association between IC and recent falls (/= 77.6) IC categories. Those with high IC (63.9%) were younger, more often males, and had lower prevalence of recent falls, disability, multimorbidity, and polypharmacy. Logistic regression models including IC as a continuous variable revealed a significant association between higher IC and lower odds of falls. This association was significant in the unadjusted (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.94-0.98, p < 0.001), age- and sex-adjusted (OR 0.96, 95% CI 0.94-0.98, p < 0.001), and fully adjusted models (OR 0.96, 95% CI 0.93-0.99, p = 0.003). When considering IC as a categorical variable, unadjusted logistic regression showed a strong association between high IC and lower odds of falls (OR 0.31, 95% CI 0.16-0.60, p < 0.001). This association remained significant in both the age- and sex-adjusted (OR 0.30, 95% CI 0.15-0.59, p < 0.001) and fully adjusted models (OR 0.33, 95% CI 0.16-0.82, p = 0.007). The locomotion domain was independently associated with falls in the unadjusted (OR 0.98, 95% CI 0.97-0.99, p < 0.001), age- and sex-adjusted (OR 0.97, 95% CI 0.96-0.99, p < 0.001), and fully adjusted model (OR 0.98, 95% CI 0.96-0.99, p < 0.001). DISCUSSION: This is the first study using an MDS-HC-derived instrument to assess IC. Individuals with higher IC were less likely to report recent falls, with locomotion being an independently associated domain. CONCLUSIONS: Lower IC is linked to increased odds of falls. Interventions to maintain and improve IC, especially the locomotion domain, may reduce fall risk in community-dwelling octogenarians. |
| DOI | 10.1007/s40520-024-02822-7 |
| Custom 1 | The authors declare no competing interests. The authors declare no conflict of interest. |
| PMCID | PMC11316723 |
